Ghostbusters meets Super Mario Bros in this tale about plumbers who can't get no money, so they decide to create a ghost elimination service to get paid. Soon they get calls from the people of New York and start to catch all the Boos in the Big Apple but the major problem is when a wizard Kamek plots to use his dark magic to bring forth Bowser to destroy. Now it's up to the Boo Busters to go face to face with the ultimate evil.